Prkn - parkin RBR E3 ubiquitin protein ligase

Enables protein kinase binding activity. Involved in several processes, including cellular response to amino acid stimulus; negative regulation of neuron death; and negative regulation of synaptic transmission. Acts upstream of or within negative regulation of neuron death. Located in several cellular components, including bounding membrane of organelle; membrane raft; and postsynaptic density. Colocalizes with mitochondrion. Used to study Parkinson's disease. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2022]