Dnajb2 - DnaJ heat shock protein family (Hsp40) member B2

Predicted to enable several functions, including Hsp70 protein binding activity; chaperone binding activity; and modification-dependent protein binding activity. Predicted to be involved in several processes, including positive regulation of ATPase activity; protein refolding; and regulation of cellular protein metabolic process. Predicted to be located in inclusion body; nuclear membrane; and perinuclear region of cytoplasm. Predicted to be part of proteasome complex. Predicted to be active in cytosol. Predicted to be intrinsic component of endoplasmic reticulum membrane. Is expressed in dorsal root ganglion; facial ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Human ortholog(s) of this gene implicated in distal spinal muscular atrophy type 5. Orthologous to human DNAJB2 (DnaJ heat shock protein family (Hsp40) member B2). [provided by Alliance of Genome Resources, Apr 2022]