Scube2 - signal peptide, CUB domain, EGF-like 2

Enables hedgehog family protein binding activity. Acts upstream of or within several processes, including positive regulation of chondrocyte proliferation; positive regulation of osteoblast differentiation; and positive regulation of smoothened signaling pathway. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; neural ectoderm; skeleton; and tongue. Orthologous to human SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]