Pclo - piccolo (presynaptic cytomatrix protein)

Enables calcium ion binding activity; calcium-dependent phospholipid binding activity; and transcription corepressor binding activity. Involved in several processes, including positive regulation of synaptic vesicle recycling; presynaptic active zone assembly; and regulation of endosome size. Located in several cellular components, including cytoplasmic vesicle; distal axon; and rod spherule. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic active zone cytoplasmic component. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein). [provided by Alliance of Genome Resources, Apr 2022]