Dhodh - dihydroorotate dehydrogenase

Enables dihydroorotase activity and dihydroorotate dehydrogenase activity. Involved in 'de novo' UMP biosynthetic process and UDP biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; branchial arch; limb bud; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Apr 2022]