Klk4 - kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)

Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Acts upstream of or within amelogenesis; extracellular matrix disassembly; and protein catabolic process. Predicted to be located in extracellular region. Predicted to be active in secretory granule. Is expressed in epididymis; ileum; prostate gland; skin; and upper jaw incisor. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A1 and prostate cancer. Orthologous to human KLK4 (kallikrein related peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]