Kcnip3 - Kv channel interacting protein 3, calsenilin

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding activity; and transcription cis-regulatory region binding activity. Involved in protein localization to plasma membrane; regulation of potassium ion transmembrane transport; and response to magnesium ion. Acts upstream of or within several processes, including behavioral response to pain; negative regulation of transcription by RNA polymerase II; and sensory perception of pain. Located in cytosol and nucleus. Part of protein-DNA complex and voltage-gated potassium channel complex. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and spinal cord. Orthologous to human KCNIP3 (potassium voltage-gated channel interacting protein 3). [provided by Alliance of Genome Resources, Apr 2022]