Foxo1 - forkhead box O1

Enables several functions, including DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to insulin stimulus; cellular response to nitric oxide; and negative regulation of fat cell differentiation. Acts upstream of or within several processes, including insulin receptor signaling pathway; neuronal stem cell population maintenance; and positive regulation of cellular biosynthetic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1). [provided by Alliance of Genome Resources, Apr 2022]