Adar - adenosine deaminase, RNA-specific

Enables double-stranded RNA adenosine deaminase activity. Involved in several processes, including adenosine to inosine editing; negative regulation of protein kinase activity by regulation of protein phosphorylation; and positive regulation of viral genome replication. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; immune system development; and regulation of gene expression. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (adenosine deaminase RNA specific). [provided by Alliance of Genome Resources, Apr 2022]