Arl6 - ADP-ribosylation factor-like 6

Predicted to enable GTP binding activity. Involved in protein localization to non-motile cilium. Acts upstream of or within several processes, including fat cell differentiation; protein transport from ciliary membrane to plasma membrane; and retina layer formation. Located in cytosol and membrane. Is expressed in several structures, including central nervous system; chondrocranium; embryo endoderm; forelimb bud; and node. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Orthologous to human ARL6 (ADP ribosylation factor like GTPase 6). [provided by Alliance of Genome Resources, Apr 2022]