Tdp2 - tyrosyl-DNA phosphodiesterase 2

Predicted to enable several functions, including metal ion binding activity; phosphoric diester hydrolase activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair and neuron development. Predicted to act upstream of or within DNA repair. Predicted to be located in aggresome and nuclear body. Predicted to be active in PML body and cytoplasm. Is expressed in several structures, including alimentary system; limb; liver; spleen; and testis. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 23. Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2). [provided by Alliance of Genome Resources, Apr 2022]