Predicted to enable rRNA (guanine) methyltransferase activity and rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and rRNA methylation. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including central nervous system; gonad; liver; retina; and spleen. Orthologous to human FTSJ3 (FtsJ RNA 2'-O-methyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]