Sh3glb1 - SH3-domain GRB2-like B1 (endophilin)

Enables fatty acid binding activity and lysophosphatidic acid acyltransferase activity. Involved in several processes, including positive regulation of autophagosome assembly; positive regulation of phosphatidylinositol 3-kinase activity; and regulation of intrinsic apoptotic signaling pathway by p53 class mediator. Acts upstream of or within 'de novo' posttranslational protein folding; phosphatidic acid biosynthetic process; and positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. Located in membrane. Part of protein-containing complex. Is expressed in cerebellum; embryo; endolymphatic appendage; otocyst; and spleen. Orthologous to human SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1). [provided by Alliance of Genome Resources, Apr 2022]