Calcrl - calcitonin receptor-like

Enables calcitonin gene-related peptide receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; heart development; and positive regulation of smooth muscle cell proliferation. Predicted to be located in endoplasmic reticulum; endosome; and lysosome. Predicted to be part of CGRP receptor complex and adrenomedullin receptor complex. Predicted to be active in plasma membrane. Is expressed in dorsal root ganglion and lung epithelium. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CALCRL (calcitonin receptor like receptor). [provided by Alliance of Genome Resources, Apr 2022]