Ramp2 - receptor (calcitonin) activity modifying protein 2

Enables coreceptor activity. Involved in several processes, including cell-cell junction assembly; circulatory system development; and negative regulation of endothelial cell apoptotic process. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of adrenomedullin receptor complex and amylin receptor complex 2. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Is expressed in several structures, including cardiovascular system; forelimb bud; gut; liver; and prostate gland lobe. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RAMP2 (receptor activity modifying protein 2). [provided by Alliance of Genome Resources, Apr 2022]