Cacng3 - calcium channel, voltage-dependent, gamma subunit 3

Predicted to enable several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and voltage-gated calcium channel activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane and protein targeting. Located in glutamatergic synapse and somatodendritic compartment. Is integral component of postsynaptic density membrane. Part of AMPA glutamate receptor complex. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in childhood absence epilepsy and macular degeneration. Orthologous to human CACNG3 (calcium voltage-gated channel auxiliary subunit gamma 3). [provided by Alliance of Genome Resources, Apr 2022]