Grik2 - glutamate ionotropic receptor kainate type subunit 2

Enables several functions, including PDZ domain binding activity; enzyme binding activity; and kainate selective glutamate receptor activity. Involved in several processes, including negative regulation of glutamatergic synaptic transmission; positive regulation of neuron apoptotic process; and regulation of JNK cascade. Located in dendrite cytoplasm; perikaryon; and terminal bouton. Is integral component of plasma membrane. Part of ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in Huntington's disease and autosomal recessive non-syndromic intellectual disability. Orthologous to human GRIK2 (glutamate ionotropic receptor kainate type subunit 2). [provided by Alliance of Genome Resources, Apr 2022]