Cltc - clathrin heavy chain

Enables several functions, including ankyrin binding activity; heat shock protein binding activity; and protein C-terminus binding activity. Involved in Golgi organization; endocytosis; and mitotic cell cycle. Located in T-tubule and spindle. Part of clathrin coat. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 56. Orthologous to human CLTC (clathrin heavy chain). [provided by Alliance of Genome Resources, Apr 2022]