Cdk1 - cyclin-dependent kinase 1

Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and histone kinase activity. Involved in several processes, including Golgi disassembly; positive regulation of protein import into nucleus; and ventricular cardiac muscle cell development. Acts upstream of or within negative regulation of gene expression. Located in cytoplasm and nucleus. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1). [provided by Alliance of Genome Resources, Apr 2022]