Irf3 - interferon regulatory factor 3

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to virus; positive regulation of type I interferon production; and type I interferon signaling pathway. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; negative regulation of macromolecule metabolic process; and regulation of defense response. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3). [provided by Alliance of Genome Resources, Apr 2022]