Reck - reversion-inducing-cysteine-rich protein with kazal motifs

Enables Wnt-protein binding activity; coreceptor activity involved in canonical Wnt signaling pathway; and endopeptidase inhibitor activity. Involved in several processes, including negative regulation of metalloendopeptidase activity; positive regulation of canonical Wnt signaling pathway; and regulation of establishment of blood-brain barrier. Acts upstream of or within several processes, including blood vessel maturation; embryo implantation; and embryonic forelimb morphogenesis. Located in plasma membrane. Part of Wnt signalosome. Is expressed in diaphragm; genitourinary system; and skeletal musculature. Orthologous to human RECK (reversion inducing cysteine rich protein with kazal motifs). [provided by Alliance of Genome Resources, Apr 2022]