Sec61a1 - Sec61 alpha 1 subunit (S. cerevisiae)

Enables ribosome binding activity and transmembrane transporter activity. Involved in pronephric nephron development. Predicted to be located in endoplasmic reticulum membrane and rough endoplasmic reticulum. Predicted to be part of Sec61 translocon complex. Is expressed in cerebral cortex; jaw; skeleton; and vibrissa. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]