Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within response to hypoxia and transcription by RNA polymerase II. Located in mitochondrion and nuclear speck. Is expressed in several structures, including central nervous system; genitourinary system; and lung. Orthologous to human HIF3A (hypoxia inducible factor 3 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]