Hnrnpa2b1 - heterogeneous nuclear ribonucleoprotein A2/B1

Enables pre-mRNA intronic binding activity. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1). [provided by Alliance of Genome Resources, Apr 2022]