Ppp2r1a - protein phosphatase 2, regulatory subunit A, alpha

Enables protein serine/threonine phosphatase activity. Acts upstream of or within several processes, including nuclear division; peptidyl-serine dephosphorylation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol and glutamatergic synapse. Part of protein phosphatase type 2A complex. Is active in synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 36. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha). [provided by Alliance of Genome Resources, Apr 2022]