Prkn - parkin RBR E3 ubiquitin protein ligase

Enables ubiquitin protein ligase activity. Involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway; positive regulation of cellular protein metabolic process; and positive regulation of dendrite extension. Acts upstream of or within several processes, including catecholamine metabolic process; chemical synaptic transmission; and mitophagy. Located in mitochondrion; neuron projection; and nucleus. Part of protein-containing complex. Is expressed in several structures, including face; nervous system; pancreas; sensory organ; and skeleton. Used to study Parkinson's disease 2. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2022]