Fbxw7 - F-box and WD-40 domain protein 7

Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of osteoclast development; and positive regulation of proteolysis involved in cellular protein catabolic process. Acts upstream of or within several processes, including negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; protein destabilization; and vasculogenesis. Located in several cellular components, including Golgi apparatus; nucleolus; and perinuclear region of cytoplasm. Is expressed in brain; early conceptus; genitourinary system; and skeletal muscle tissue. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]