Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Part of ubiquitin ligase complex. Is expressed in several structures, including branchial arch; ear; forelimb bud; heart; and notochord. Orthologous to human FBXO8 (F-box protein 8). [provided by Alliance of Genome Resources, Apr 2022]