Ptpro - protein tyrosine phosphatase, receptor type, O

Enables protein tyrosine phosphatase activity. Involved in negative regulation of glomerular filtration. Predicted to be located in apical plasma membrane; dendritic spine; and lateral plasma membrane. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and plasma membrane. Predicted to be integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O). [provided by Alliance of Genome Resources, Apr 2022]