Runx1 - RUNX family transcription factor 1

Enables promoter-specific chromatin binding activity and sequence-specific double-stranded DNA binding activity. Involved in several processes, including ovulation; positive regulation of progesterone secretion; and response to denervation involved in regulation of muscle adaptation. Located in chromatin and nucleus. Used to study middle cerebral artery infarction. Biomarker of endometriosis. Human ortholog(s) of this gene implicated in acute myeloid leukemia and esophagus squamous cell carcinoma. Orthologous to human RUNX1 (RUNX family transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]