Nox4 - NADPH oxidase 4

Enables protein tyrosine kinase binding activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of nitrogen compound metabolic process; and superoxide anion generation. Acts upstream of or within bone resorption; cardiac muscle cell differentiation; and cellular response to glucose stimulus. Located in several cellular components, including mitochondrion; nucleus; and perinuclear region of cytoplasm. Is expressed in embryo; heart; metanephros; renal cortex; and ventricle compact myocardium. Orthologous to human NOX4 (NADPH oxidase 4). [provided by Alliance of Genome Resources, Apr 2022]