Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; protein ubiquitination; and response to endoplasmic reticulum stress. Predicted to be located in cis-Golgi network membrane; endoplasmic reticulum; and lysosomal membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human RNF183 (ring finger protein 183). [provided by Alliance of Genome Resources, Apr 2022]