Aplf - aprataxin and PNKP like factor

Predicted to enable DNA-(apurinic or apyrimidinic site) endonuclease activity; nuclease activity; and nucleotide binding activity. Predicted to be involved in double-strand break repair via nonhomologous end joining and single strand break repair. Predicted to act upstream of or within positive regulation of DNA ligation and regulation of isotype switching. Predicted to be located in nucleoplasm. Predicted to be active in nucleus and site of double-strand break. Orthologous to human APLF (aprataxin and PNKP like factor). [provided by Alliance of Genome Resources, Apr 2022]