Enables AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Involved in protein autophosphorylation and regulation of clathrin-dependent endocytosis. Located in cell leading edge and terminal bouton. Part of clathrin complex. Is active in presynapse. Orthologous to human AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]