Man1b1 - mannosidase, alpha, class 1B, member 1

Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing; mannose trimming involved in glycoprotein ERAD pathway; and trimming of terminal mannose on B branch. Predicted to be located in cytoplasmic vesicle and endoplasmic reticulum quality control compartment. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MAN1B1 (mannosidase alpha class 1B member 1). [provided by Alliance of Genome Resources, Apr 2022]