Dock8 - dedicator of cytokinesis 8

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including positive regulation of GTPase activity; positive regulation of T cell migration; and positive regulation of establishment of T cell polarity. Predicted to act upstream of or within several processes, including dendritic cell migration; immunological synapse formation; and memory T cell proliferation. Predicted to be located in cytoplasm and leading edge membrane. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in atopic dermatitis; bacterial infectious disease; hyper IgE recurrent infection syndrome 2; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; and viral infectious disease (multiple). Orthologous to human DOCK8 (dedicator of cytokinesis 8). [provided by Alliance of Genome Resources, Apr 2022]