Predicted to enable frizzled binding activity and heparin binding activity. Predicted to be involved in blood vessel remodeling; positive regulation of non-canonical Wnt signaling pathway; and sprouting angiogenesis. Predicted to act upstream of or within angiogenesis; branching involved in labyrinthine layer morphogenesis; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in extracellular region. Orthologous to human RSPO3 (R-spondin 3). [provided by Alliance of Genome Resources, Apr 2022]