Hesx1 - HESX homeobox 1

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; protein C-terminus binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and pituitary gland development. Predicted to act upstream of or within with a negative effect on canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including ERK1 and ERK2 cascade; animal organ development; and cell surface receptor signaling pathway. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in septooptic dysplasia. Orthologous to human HESX1 (HESX homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]