Pkd2 - polycystin 2, transient receptor potential cation channel

Enables muscle alpha-actinin binding activity. Involved in positive regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum and membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration. Orthologous to human PKD2 (polycystin 2, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Apr 2022]