Cfhr4 - complement factor H-related 4

Predicted to enable complement component C3b binding activity and heparin binding activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to human CFH (complement factor H); CFHR3 (complement factor H related 3); and CFHR4 (complement factor H related 4). [provided by Alliance of Genome Resources, Apr 2022]