Med1 - mediator complex subunit 1

Enables DNA binding activity; nuclear receptor binding activity; and transcription coregulator activity. Contributes to ubiquitin protein ligase activity. Involved in several processes, including cellular response to thyroid hormone stimulus; positive regulation of transcription by RNA polymerase II; and protein ubiquitination. Located in chromatin and nucleus. Part of protein-DNA complex and ubiquitin ligase complex. Orthologous to human MED1 (mediator complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]