Predicted to enable PDZ domain binding activity and ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including excitatory chemical synaptic transmission; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of neurotransmitter receptor activity. Predicted to be located in asymmetric, glutamatergic, excitatory synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in glutamatergic synapse; postsynaptic density; and synaptic membrane. Predicted to be integral component of postsynaptic density membrane. Orthologous to human SHISA6 (shisa family member 6). [provided by Alliance of Genome Resources, Apr 2022]