Predicted to enable Notch binding activity and identical protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in negative regulation of Rho protein signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of or within circulatory system development; negative regulation of Notch signaling pathway; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex and MKS complex. Orthologous to human KCTD10 (potassium channel tetramerization domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]