Gsdma3 - gasdermin A3

Enables cardiolipin binding activity and wide pore channel activity. Involved in mammary gland development; protein complex oligomerization; and pyroptosis. Acts upstream of or within several processes, including negative regulation of timing of anagen; regulation of signal transduction; and skin development. Located in several cellular components, including cytosol; mitochondrion; and nucleus. Is integral component of membrane. Is expressed in foregut; hair root sheath; and hair shaft. Orthologous to human GSDMA (gasdermin A). [provided by Alliance of Genome Resources, Apr 2022]