Otulin - OTU deubiquitinase with linear linkage specificity

Enables thiol-dependent deubiquitinase. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; protein linear deubiquitination; and regulation of signal transduction. Located in cytoplasm. Part of LUBAC complex. Is expressed in several structures, including branchial arch; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Human ortholog(s) of this gene implicated in otulipenia. Orthologous to human OTULIN (OTU deubiquitinase with linear linkage specificity). [provided by Alliance of Genome Resources, Apr 2022]