Human
MAF - MAF BZIP Transcription Factor
Alias:
CCA4
AYGRP
c-MAF
CTRCT21
Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
6
2
398116 bp
38.49
329
10
13
20
MAF Genetics information (-)
GRCh38
Chr 16: 79202622 - 79600737
Adjacent gene of MAF:6
Sequence Homology
Gene Length
Human
Chr 16
398116 bp
Mouse
Chr 8
3642 bp
Rat
Chr 19
359296 bp
Exon Count
Human
NM_005360.5
2
Mouse
NM_001025577.2
2
Rat
NM_019318.2
2
Transcript Length
Human
NM_005360.5
2669 bp
Mouse
NM_001025577.2
3642 bp
Rat
NM_019318.2
1945 bp
homology
Sequence Alignment
Human
NM_005360.5
100%
Mouse
NM_001025577.2
87.4%
Rat
NM_019318.2
87.1%
Protein Length
Human
NP_005351.2
403 aa
Mouse
NP_001020748.2
370 aa
Rat
NP_062191.2
369 aa
Protein homology
Sequence Alignment
Human
NP_005351.2
100%
Mouse
NP_001020748.2
89.8%
Rat
NP_062191.2
89.6%
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
No data available
Transcripts & Proteins
There are 6 transcripts and 6 protein isoforms for MAF gene.
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
1
2669
2
1212
NP_005351.2
403
2
6900
1
1122
NP_001026974.1
373
3
12295
3
1152
XP_024306047.1
383
4
4675
3
1152
XP_016878724.1
383
5
3317
3
1152
XP_016878723.1
383
6
2250
3
1152
XP_016878722.1
383
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Nervous system
Endocrine & Immune system
Respiratory & Circulatory system
Digestive system
Urinary & Reproductive system
Other systems
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
No data available
Related Drugs
Name
CAS Number
Status
Phase
Link
Deoxyuridine-5'-Triphosphate
1173-82-6
Experimental
Not
Glucagon
16941-32-5
Approved
Not
2 Results, 10 per Page
1
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
Wechat
Mutation Direct
Sequence
Comparison
Al agent
Sources
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