Aicda - activation-induced cytidine deaminase

Predicted to enable several functions, including hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; identical protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cytidine deamination; negative regulation of DNA methylation-dependent heterochromatin assembly; and nucleic acid metabolic process. Predicted to act upstream of or within cellular response to lipopolysaccharide; defense response to bacterium; and isotype switching. Predicted to be part of protein-containing complex. Predicted to be active in P-body and nucleus. Human ortholog(s) of this gene implicated in hyperimmunoglobulin syndrome and immunodeficiency with hyper-IgM type 2. Orthologous to human AICDA (activation induced cytidine deaminase). [provided by Alliance of Genome Resources, Apr 2022]