E2f1 - E2F transcription factor 1

Enables protein kinase binding activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hypoxia; cellular response to nerve growth factor stimulus; and positive regulation of glial cell proliferation. Located in cytoplasm and nucleus. Biomarker of Huntington's disease and pancreatic cancer. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]