Irs2 - insulin receptor substrate 2

Enables phosphatidylinositol 3-kinase binding activity and protein kinase binding activity. Involved in several processes, including negative regulation of B cell apoptotic process; positive regulation of B cell proliferation; and positive regulation of insulin secretion. Acts upstream of or within several processes, including animal organ development; insulin receptor signaling pathway; and positive regulation of mesenchymal cell proliferation. Located in cytosol and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including brain ventricular layer; hindlimb digit skin; jaw; metanephros; and thymus primordium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2). [provided by Alliance of Genome Resources, Apr 2022]