Enables thiol-dependent deubiquitinase. Acts upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including USP17L10 (ubiquitin specific peptidase 17 like family member 10); USP17L11 (ubiquitin specific peptidase 17 like family member 11); and USP17L12 (ubiquitin specific peptidase 17 like family member 12). [provided by Alliance of Genome Resources, Apr 2022]